James E. Corban

Systematic mapping of chromatin dysregulation driven by viral transcriptional regulators at scale

The paper maps chromatin dysregulation caused by viral transcriptional regulators using PROD-ATAC, identifying vTRs that remodel chromatin and reveal shared host transcription factor networks.

Viral transcriptional regulators extensively rewire host pathways through diverse mechanisms

This study systematically profiles 95 viral transcriptional regulators (vTRs) across multiple assays, revealing their diverse mechanisms of rewiring host pathways to promote viral replication and disease links.

Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts

This study introduces PhageMaP, a high-throughput method to assess gene essentiality in bacteriophages across diverse hosts and uses it to engineer synthetic phages with enhanced infectivity.