Paolo G. V. Martini

KLF7 is a general inducer of human pluripotency

This study identifies KLF7 as a key inducer of human pluripotency, showing its role in reprogramming somatic cells and enhancing chemical resetting to naive pluripotent stem cells.

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential

This study develops a feeder-free serum-coated system for culturing naive human pluripotent stem cells, maintaining their developmental potential and reducing contamination and mutations.

signifinder enables the identification of tumor cell states and cancer expression signatures in bulk, single-cell and spatial transcriptomic data

signifinder is an R package that collects, implements, and compares cancer-related gene expression signatures across bulk, single-cell, and spatial transcriptomic data to improve reproducibility and usability.

Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells

This study converts conventional human pluripotent stem cells into trophoblast stem cells using a chemical resetting protocol that induces TSC markers and placental imprinted genes.

Allelic expression analysis of Imprinted and X-linked genes from bulk and single-cell transcriptomes

BrewerIX analyzes allelic expression of imprinted and X-linked genes from bulk and single-cell transcriptomes to identify aberrant expression patterns in various biological contexts.

Lipid utilization in skeletal muscle cells is modulated in vitro and in vivo by specific miRNAs

The paper identifies miR-27a-3p and miR-142-3p as key regulators of lipid utilization in skeletal muscle by analyzing single-cell mRNA and miRNA signatures.