Alexandra Salvi

The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice

This study shows that Rac1 activation in the dorsomedial striatum of male mice contributes to alcohol-induced structural plasticity and goal-directed learning.

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

This study shows that Prosapip1 in the dorsal hippocampus is essential for synaptic protein localization, long-term potentiation, and spatial memory.

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis

The paper shows that mTORC1 activation in the nucleus accumbens of alcohol-consuming mice represses glycolysis via miR-34a-5p-mediated translation repression of Aldolase A, leading to reduced L-lactate and decreased alcohol intake.

IDENTIFICATION OF NOVEL BDNF-SPECIFIC CORTICOSTRIATAL CIRCUITRIES

This study maps BDNF-specific corticostriatal circuits in mice, revealing distinct projections from different cortical regions to the dorsomedial and dorsolateral striatum.

Splicing impact of deep exonic missense variants in CAPN3 explored systematically by minigene functional assay

The paper systematically assesses the splicing impact of deep exonic missense variants in CAPN3 using minigene assays, revealing that eight variants disrupt splicing and highlight limitations in current computational tools.