Zachary W. Hoisington

The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice

This study shows that Rac1 activation in the dorsomedial striatum of male mice contributes to alcohol-induced structural plasticity and goal-directed learning.

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

This study shows that Prosapip1 in the dorsal hippocampus is essential for synaptic protein localization, long-term potentiation, and spatial memory.

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis

The paper shows that mTORC1 activation in the nucleus accumbens of alcohol-consuming mice represses glycolysis via miR-34a-5p-mediated translation repression of Aldolase A, leading to reduced L-lactate and decreased alcohol intake.

The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice