Khanhky Phamluong

BDNF in Ventrolateral Orbitofrontal Cortex to Dorsolateral Striatum Circuit Moderates Alcohol Consumption and Gates Alcohol Habit

This study shows that BDNF in vlOFC-to-DLS neurons reduces alcohol intake by decreasing habitual seeking, but not sucrose intake.

The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice

This study shows that Rac1 activation in the dorsomedial striatum of male mice contributes to alcohol-induced structural plasticity and goal-directed learning.

Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

This study shows that Prosapip1 in the dorsal hippocampus is essential for synaptic protein localization, long-term potentiation, and spatial memory.

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis

The paper shows that mTORC1 activation in the nucleus accumbens of alcohol-consuming mice represses glycolysis via miR-34a-5p-mediated translation repression of Aldolase A, leading to reduced L-lactate and decreased alcohol intake.

Sex Differences In The Interaction Between Alcohol And mTORC1

This study investigates sex differences in mTORC1 activation and rapamycin's effect on alcohol use in male and female rodents.

IDENTIFICATION OF NOVEL BDNF-SPECIFIC CORTICOSTRIATAL CIRCUITRIES

This study maps BDNF-specific corticostriatal circuits in mice, revealing distinct projections from different cortical regions to the dorsomedial and dorsolateral striatum.

BRAIN-DERIVED NEUROTROPHIC FACTOR IN AN ORBITOFRONTAL CORTICAL-DORSOLATERAL STRIATAL CIRCUIT GATES ALCOHOL CONSUMPTION

This study shows that BDNF in the vlOFC-DLS circuit reduces alcohol consumption in rodents, but not saccharin intake or motor cortex BDNF effects.

Brain-Specific Inhibition of mTORC1 by a Dual Drug Strategy: A Novel Approach for the Treatment of Alcohol Use Disorder

This study demonstrates that dual drug administration of RapaLink-1 and RapaBlock selectively inhibits mTORC1 in the brain while protecting it in the periphery, reducing side effects and moderating alcohol use in mice.

cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use

This study identifies the cAMP-Fyn signaling pathway in dorsomedial striatum direct pathway neurons as a driver of excessive alcohol consumption in mice.

Differential Correlation of Serum BDNF and microRNA Content in Rats with Rapid or Late Onset of Heavy Alcohol Use

The paper examines how heavy alcohol use affects BDNF and microRNA levels in rats, finding distinct patterns between Rapid and Late Onset drinkers.

mTORC1 IN THE ORBITOFRONTAL CORTEX PROMOTES HABITUAL ALCOHOL SEEKING

This study shows that mTORC1 in the orbitofrontal cortex drives habitual alcohol seeking, with GluN2B recruitment during withdrawal activating mTORC1 and promoting this behavior.