Author

Shixin Ma

Northeastern UniversityORCID 0000-0002-7724-3807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Fei TengiD· 4 shared Yingjia Yao· 4 shared Zexu LiiD· 4 shared Zihan LiiD· 4 shared Chunge ZhongiD· 2 shared Han ZhangiD· 2 shared Lumen ChaoiD· 2 shared Xiaolong ChengiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Fei TengORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity

Brandon M. Oswald, Lisa M. DeCamp, Joseph Longo, Michael S. Dahabieh, Nicholas Bunda, Benjamin K. Johnson, McLane J. Watson, Shixin Ma, Samuel E.J. Preston, Ryan D. Sheldon, Michael P. Vincent, Abigail E. Ellis, Molly T. Soper-Hopper, Christine N. Isaguirre, Dahlya Kamarudin, , Russell G. Jones

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

Nature Metabolism · Dec 9, 2025Peer-reviewedImmunology

A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope

Xiao‐Feng Wang, Xiaolong Cheng, Zexu Li, Shixin Ma, Han Zhang, Zhisong Chen, Yingjia Yao, Zihan Li, Chunge Zhong, You Li, Yunhan Zhang, Vipin K. Menon, Lumen Chao, Wei Li, Fei Teng

The paper benchmarks multiple base editors and develops a model to predict editing efficiency, validating edits for disease-associated variants and identifying cancer-related SNVs.

bioRxiv · Dec 17, 2024 · PreprintMolecular Biology

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Chunge Zhong, Wenjie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, , Fei Teng

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Nature Communications · Jun 29, 2024Peer-reviewedCancer Biology

Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems

Zexu Li, Zihan Li, Xiaolong Cheng, Xiaofeng Wang, Shixin Ma, Shengnan Wang, Zhiyan Lu, Han Zhang, Wenchang Zhao, Zhisong Chen, Yingjia Yao, Lumen Chao, Wei Li, Fei Teng

The paper evaluates CRISPR-Cas13 systems and finds that they have intrinsic RNA targets in mammalian cells, which can affect lentiviral particle production and limit their utility.

bioRxiv · May 14, 2022 · PreprintMolecular Biology

A Chemical-Enhanced System for CRISPR-Based Nucleic Acid Detection

Zihan Li, Wenchang Zhao, Shixin Ma, Zexu Li, Yingjia Yao, Fei Teng

This paper introduces CECRID, a CRISPR-based detection system enhanced with L-proline to improve sensitivity and robustness for nucleic acid detection, particularly for SARS-CoV-2.

Biosensors and Bioelectronics · Jul 9, 2021Peer-reviewedMolecular Biology