Author

Matthew A. Mitsche

The University of Texas Southwestern Medical CenterORCID 0000-0003-3237-5803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Chai-wan Kim· 1 shared Chalermchai KhemtongiD· 1 shared Chao LiiD· 1 shared Chongshan DaiiD· 1 shared Craig R. MalloyiD· 1 shared Gaurav SharmaiD· 1 shared Goncalo Dias do ValeiD· 1 shared Helen H. HobbsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Chai-wan Kim

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2 papers

Recent·Most cited

TM6SF2 is a cholesterol-bound homomultimeric ER membrane protein that binds ApoB and is required for bulk lipidation of VLDL

Sen Hong, Jin Wang, Matthew A. Mitsche, Jonathan C. Cohen, Xiaochun Li, Helen H. Hobbs

This study determines the structure of TM6SF2 and shows its role in lipidation of ApoB-containing lipoproteins, with a variant affecting cholesterol binding and function.

bioRxiv · Sep 28, 2026 · PreprintCell Biology

Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

Chai-wan Kim, Goncalo Dias do Vale, Xiaorong Fu, Jeffrey G. McDonald, Chongshan Dai, Chao Li, Zhao V. Wang, Gaurav Sharma, Chalermchai Khemtong, Craig R. Malloy, Stanisław Deja, Shawn C. Burgess, Matthew A. Mitsche, Jay D. Horton

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

Journal of Clinical Investigation · Apr 30, 2026Peer-reviewedCell Biology