Carol M. Manhart

Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence

This study identifies aberrant cytoplasmic MLH1 localization in sub-clonal breast cancer cells as a driver of endocrine resistance, showing it predicts response to CDK4/6 inhibitors.

The mismatch repair factor Mlh1-Pms1 uses ATP to compact and remodel DNA

This study shows that Mlh1-Pms1 uses ATP to compact and remodel DNA, which is important for mismatch repair and genome stability.

The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repair

This paper shows that the Mlh1-Pms1 endonuclease uses ATP binding to recognize DNA discontinuities, preserving them as strand discrimination signals for mismatch repair.

Exo1-protected DNA nicks direct crossover formation in meiosis

This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.

mlh3 separation of function and endonuclease defective mutants display an unexpected effect on meiotic recombination outcomes

The paper identifies mlh3 alleles with distinct separation of function phenotypes in meiosis and DNA mismatch repair, revealing the role of protein-protein interactions in regulating Mlh1-Mlh3 activity.