David W. Dawson

This study shows that Xist-mediated gene silencing supports CD4+ T cell persistence and colitogenic capacity, contributing to autoimmunity.

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

This study identifies aPKC enzymes as regulators of macropinocytosis in PDAC cells under glutamine stress, showing their role in cell survival and tumor growth.

This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.