Joseph M. Josephides

Local B cell maturation and mast cell regulation of choroid plexus function in early life.

The paper uses single-cell sequencing to study immune cell development in the choroid plexus, showing B cell maturation and mast cell regulation impact brain development.

Alzheimer's disease causes bone marrow myelopoiesis dysfunction

This study identifies impaired bone marrow myelopoiesis in Alzheimer's disease, driven by type I interferon signaling, and shows that targeting this pathway improves myeloid function and cognitive outcomes.

MnM: a machine learning approach to detect replication states and genomic subpopulations for single-cell DNA replication timing disentanglement

MnM detects replication states and genomic subpopulations in single-cell DNA data, enabling accurate replication timing profiles from heterogeneous samples.

Kronos scRT: a uniform framework for single-cell replication timing analysis

Kronos scRT enables single-cell replication timing analysis without cell sorting, analyzing thousands of cells from mouse and human cell lines.