Author

Jian Shi

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cell Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Corrine R. KlimentiD· 2 shared Qianjiang HuiD· 2 shared Andrea Grosso· 1 shared Brett A. KaufmaniD· 1 shared Byron W. Chuan· 1 shared Chen Chen· 1 shared Christine Halleux· 1 shared Claudette M. St. CroixiD· 1 shared

Activity by Year

2016-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPathology

Corrine R. KlimentORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

LNA043 and ANGPTL3 Interactions with Integrin α5β1 and Fibronectin Drive Distinct Stromal and Immune Responses

Andrea Grosso, Stefano Cucuzza, Elsa Gambs, Thomas Lapointe, Truc Huynh, Guray Kuzu, Frederik King, Kenneth Ng, Jian Shi, Markus Vogel, Nicole Gerwin, Christine Halleux, Mara Fornaro

The paper investigates how LNA043 and ANGPTL3 interact with integrin α5β1 and fibronectin to drive distinct stromal and immune responses in osteoarthritis.

bioRxiv · Sep 24, 2026 · PreprintCell Biology

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis

Qianjiang Hu, Ugochi Onwuka, Nayra Cárdenes, M Packwood, E L Huang, Jian Shi, M. Camila Melo-Narváez, Puja Dutta, Zihe Zhou, Delphine Beaulieu, Byron W. Chuan, Pavan Suresh, Kevin Redding, Laura-Marie Twardowski, Scarlett Varley, , Mélanie Königshoff

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

bioRxiv · Jul 18, 2026 · PreprintPathology

Adenine nucleotide translocase 2 (ANT2) deficiency reprograms ferroptosis in alveolar progenitor cells to promote emphysema

Ugonna Mbaekwe, Jian Shi, Nai‐Chun Ting, Qianjiang Hu, Sébastien Gingras, Melanie Koenigshoff, Corrine R. Kliment

This study shows that ANT2 deficiency in AT2 cells promotes ferroptosis and emphysema by impairing bioenergetics and self-renewal.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo

Chen Chen, Jian Shi, Hong Hwa Lim, Sachiko Tamura, Kazuhiro Maeshima, Uttam Surana, Lu Gan

This study uses electron cryotomography to show that budding yeast chromatin lacks 30-nm fibers and is in an open configuration, suggesting transcription regulation through local nucleosome interactions.

Molecular Biology of the Cell · Nov 1, 2016Peer-reviewedCell Biology