Roderick J. O’Sullivan

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.

This study identifies TRIM24's role in ALT telomere maintenance through chromatin signaling, showing it promotes telomere DNA synthesis via SUMO-dependent mechanisms.