Author

Maximilian M. L. Knott

German Cancer Research CenterORCID 0000-0002-6995-3702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:deconvolution· 1

Frequent Co-Authors

Alina Ritter· 2 shared Florencia Cidre‐AranaziD· 2 shared Florian H. GeyeriD· 2 shared Kimberley M. HansseniD· 2 shared Malenka ZimmermanniD· 2 shared Thomas G. P. GrünewaldiD· 2 shared A. Katharina CeranskiiD· 1 shared Ahmed SadikiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alina Ritter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma

Florencia Cidre‐Aranaz, Florian H. Geyer, Tilman L. B. Hölting, Kimberley M. Hanssen, Tobias Faehling, Alina Ritter, Malenka Zimmermann, Lianghao Mao, Javier Alonso, Ana Sastre, Ashok Kumar Jayavelu, Maximilian M. L. Knott, Julian Musa, Thomas G. P. Grünewald

This study identifies cIAP1 as a tumor suppressor in Ewing sarcoma, showing that its re-expression inhibits proliferation and tumor growth in vitro and in vivo.

Cancer Letters · Mar 2, 2026Peer-reviewedCancer Biology

Dynamic Control of Argonautes by a Rapidly Evolving Immunological Switch

Chee Kiang Ewe, Guy Teichman, Shir Weiss, Maximilian M. L. Knott, Sarit Anava, Hila Gingold, Mario Bardan Sarmiento, Emily R. Troemel, Oded Rechavi

The paper identifies PALS-22 as a regulator of AGO expression in C. elegans, showing its role in balancing immunity and germline health through modulation of RNAi and epigenetic inheritance.

Current Biology · Jun 9, 2025Peer-reviewedGenetics

Dynamic oncogene activity metabolically reprograms the tryptophan-kynurenine-AHR axis driving immune evasion and tumor progression in Ewing sarcoma

Martha Julia Carreño-Gonzalez, Kimberley M. Hanssen, Ahmed Sadik, Alessa Henneberg, Maximilian M. L. Knott, Anna C. Ehlers, A. Katharina Ceranski, Zuzanna Kolodynska, Malenka Zimmermann, Roland Imle, Anneliene H. Jonker, Florian H. Geyer, Alina Ritter, Ana Banito, Clémence Henon, , Thomas G. P. Grünewald

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

bioRxiv · May 16, 2025 · PreprintCancer Biology