James Lucas Cairns

Decoding acute neuroinflammatory states from the 3D architecture of in vitro microglia

The paper decodes acute neuroinflammatory states in mouse microglia by analyzing their 3D cellular architecture and links lipid-endosome reorganization to the mTORC1 pathway.

Fast Single-Cell MALDI Imaging of Low-Mass Metabolites Reveals Cellular Activation Markers

The paper introduces PRISM-MS, a method for fast single-cell MALDI imaging of low-mass metabolites, and demonstrates its application in analyzing metabolome changes in LPS-stimulated microglial cells.

Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging

This paper introduces moleculaR, a computational framework for probabilistic mapping and statistical testing of metabolites in mass spectrometry imaging data.