ImmunologybioRxivPreprint
Boosting of CAR-T cells with rhabdovirus is limited by type I interferon and rapid contraction
Rebecca Burchett, Claire G. Morris, Mira Ishak…·Jonathan L. Bramson
This study shows that boosting CAR-T cells with a VSV vaccine encoding the CAR-target leads to robust expansion but rapid contraction, while TCR-mediated boosting improves persistence and tumor eradication.
DOI 10.1101/2024.11.29.626103