Author

Mackenzie Lieberman

Northern Border UniversityORCID 0000-0002-9480-3589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Scott H. OlejniczakiD· 2 shared AJ Robert McGrayiD· 1 shared Andrei V. BakiniD· 1 shared Brian G. MorrealeiD· 1 shared Bryan M. GillardiD· 1 shared Caitlin M. JamesiD· 1 shared Colin A. ChaveliD· 1 shared Craig M. BrackettiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Scott H. OlejniczakORCID

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2 papers

Recent·Most cited

p38 blockade reverses the immune suppressive tumor microenvironment in metastatic breast cancer

Priyanka Rajan, Robert A. Zollo, Yanqi Guo, Mohammed Alruwaili, Justin Zonneville, Mackenzie Lieberman, Brian G. Morreale, Caitlin M. James, Mark D. Long, Scott H. Olejniczak, Joseph J. Barbi, Scott I. Abrams, Andrei V. Bakin

This study shows that blocking p38 reduces metastasis in breast cancer by reversing immune suppression in the tumor microenvironment, primarily through effects on CD8+ T cells and myeloid cells.

bioRxiv · May 8, 2025 · PreprintCancer Biology

Endogenous CD28 drives CAR T cell responses in multiple myeloma

Mackenzie M. Lieberman, Jason H. Tong, Nkechi U. Odukwe, Colin A. Chavel, Terence J. Purdon, Rebecca Burchett, Bryan M. Gillard, Craig M. Brackett, AJ Robert McGray, Jonathan L. Bramson, Renier J. Brentjens, Kelvin P. Lee, Scott H. Olejniczak

This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.

bioRxiv · Mar 21, 2024 · PreprintCancer Biology