Jonathan L. Bramson

This study improves the reproducibility of antigen-specific T cell detection using standardized AIM assay workflows and automated analysis tools.

This study shows that boosting CAR-T cells with a VSV vaccine encoding the CAR-target leads to robust expansion but rapid contraction, while TCR-mediated boosting improves persistence and tumor eradication.

This study shows that endogenous CD28 signaling is essential for CAR T cell efficacy in multiple myeloma, and transient CD28 blockade may reduce toxicities without compromising long-term survival.