Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures
Jakob Kreye, Sukhvir K. Wright, Adriana van Casteren, Laura Stöffler, Marie-Luise Machule, S. Momsen Reincke, Marc Nikolaus, Scott van Hoof, Elisa Sánchez-Sendín, Marie A. Homeyer, César Cordero Gómez, Hans‐Christian Kornau, Dietmar Schmitz, Angela Maria Kaindl, Philipp Boehm‐Sturm, , Harald Prüß
The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.
DZNE Pub · Nov 1, 2021Peer-reviewedNeuroscience