Giacomo Donati

Functional validation of allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic option for Autosomal Dominant Leukodystrophy

This study validates allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic approach for ADLD by showing restored physiological levels and functional improvements.

Spatial and single-cell transcriptomics illuminate bat immunity and barrier tissue evolution

This study uses spatial and single-cell transcriptomics to compare bat, mouse, and human tissues, revealing immune pathway divergence and unique gene expression patterns in bat gut and lung.

Molecular and spatial design of early skin development

This study uses single-cell transcriptomics and spatial analysis to map early mouse skin development, revealing new cell types and interactions.

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

The paper investigates how Wnt/beta-catenin signaling in neighboring cells affects transcriptome heterogeneity and proliferative fate in mouse keratinocytes.