Nicholas Ambiel

This study shows actin disassembly enables myelin compaction and wrapping in the CNS by developing live-cell assays and genetic perturbations.

The paper identifies a structured RNA region, MLS, necessary and sufficient for Mbp mRNA transport to oligodendrocyte projections and shows it interacts with hnRNP-F, suggesting a structural switch model for mRNA transport to translation.

This paper develops nanobodies against CNPase, showing distinct epitopes and functional applications in imaging and as intrabodies.

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

This study shows Schwann cells promote sensory neuron excitability during development by secreting prostaglandin E2, which is essential for normal sodium channel expression and action potential firing.