Manasi Iyer

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

This study shows actin disassembly enables myelin compaction and wrapping in the CNS by developing live-cell assays and genetic perturbations.

This paper develops nanobodies against CNPase, showing distinct epitopes and functional applications in imaging and as intrabodies.

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

This study shows Schwann cells promote sensory neuron excitability during development by secreting prostaglandin E2, which is essential for normal sodium channel expression and action potential firing.

This study identifies VAMP2/3-mediated exocytosis as essential for CNS myelin membrane expansion, revealing a pathway critical for myelin formation and potential therapeutic targeting.