This paper investigates sex differences in genetic liability to modifiable Alzheimer's disease risk factors using polygenic risk scores and Mendelian randomization, finding limited and inconsistent sex-specific associations.

medRxiv · Oct 6, 2026 · PreprintGenetic & Genomic Medicine

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts

Michael C Okorie, Caroline Jonson, Alexis P. Oddi, Patricia A. Castruita, Brian Fulton‐Howard, Kristine S. Yaffe, Jennifer S. Yokoyama, Chinedu Theresa Udeh‐Momoh, Shea J. Andrews, for the Alzheimer's Disease Sequencing Project and the Healthy Aging Brain Study—Health Disparities

This paper evaluates cross-ancestry polygenic risk scores (PRS) for Alzheimer's disease across multi-ethnic populations, finding improved predictive accuracy in non-European groups.

Alzheimer s & Dementia · Jul 28, 2026Peer-reviewedGenetic & Genomic Medicine

Library docking for Cannabinoid-2 Receptor ligands

Moira M. Rachman, Christos Iliopoulos‐Tsoutsouvas, Michael Dominic Sacco, Xinyu Xu, Cheng-Guo Wu, Emma Santos, Isabella Glenn, Lu Paris, Michelle K. Cahill, Suthakar Ganapathy, Tia A. Tummino, Yurii S. Moroz, Dmytro S. Radchenko, Meri Okorie, Vivianne L. Tawfik, , Brian K. Shoichet

This study uses library docking to identify subtype-selective CB2 receptor ligands, finding improved hit rates and affinities with larger libraries and structure-based optimization.

Journal of Medicinal Chemistry · Jul 3, 2026Peer-reviewedBiochemistry