Author

Sara García‐Alonso

Instituto de Salud Carlos IIIORCID 0000-0002-0561-4146Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Gonzalo AizpuruaiD· 2 shared Laura de la Puente OvejeroiD· 2 shared Lucia Lomba-RiegoiD· 2 shared Mariano BarbacidiD· 2 shared Ana DomosteguiiD· 1 shared Carmen G. LechugaiD· 1 shared Cristina Mayor‐RuiziD· 1 shared Eduardo ZarzuelaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Gonzalo AizpuruaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 6, 2026

RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer

Laura de la Puente Ovejero, Ana Domostegui, Inés María García-Pérez…·Sara García‐Alonso

This study shows that chemogenetic degradation of RAF1 in KRAS-driven lung cancer does not replicate genetic ablation outcomes due to scaffold disruption.

DOI 10.64898/2026.06.23.733960

mouseproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 27, 2026

The HSP90-CDC37 Chaperone System Orchestrates RAF1 Kinase Activation Through a Pre-Dimerization Mechanism

Gonzalo Aizpurua, Pablo Mesa, Laura de la Puente Ovejero…·Guillermo Montoya

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

3 citations

cryo-EMexperimental assay

𝕏 PostBluesky