Author

Huilun Helen Wang

University of VirginiaORCID 0000-0002-0583-1386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Liangguang Leo LiniD· 3 shared Ling QiiD· 3 shared Zexin Jason LiiD· 2 shared Amara Bugarin-Lapuz· 1 shared Brent Pederson· 1 shared Hui WangiD· 1 shared Hui Wang· 1 shared Linxiu PaniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Liangguang Leo LinORCID

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3 papers

Recent·Most cited

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viability

Xiawei Zhang, Liangguang Leo Lin, Linxiu Pan, Xiaoqiong Wei, Huilun Helen Wang, Zexin Jason Li, Ling Qi

This paper shows that the SEL1L-HRD1 complex is essential for ERAD function and neonatal survival in mice, with specific mutations causing lethal defects.

bioRxiv · Aug 1, 2025 · PreprintCell Biology

Functional rescue of a fatal ERAD mutation via alternative splicing

Huilun Helen Wang, Zhihong Wang, Liangguang Leo Lin, Sunil Kumar Verma, Weronika Gniadzik, Hui Wang, Zexin Jason Li, Lulu Jiang, Muge N. Kuyumcu‐Martinez, Shengyi Sun, Ling Qi

This study reports the discovery of using antisense oligonucleotides (ASOs) to rescue the biallelic SEL1L C141Y variant, offering a potential therapeutic strategy.

bioRxiv · Jun 13, 2025 · PreprintCell Biology

Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

Mauricio Torres, Hui Wang, Brent Pederson, Liangguang Leo Lin, Huilun Helen Wang, Amara Bugarin-Lapuz, Zhen Zhao, Ling Qi

This study shows that SEL1L-HRD1 ERAD is essential for Purkinje cell function and causes progressive cerebellar ataxia in mice.

JCI Insight · Oct 1, 2024Peer-reviewedNeuroscience