Nascent transcript O-MAP reveals the molecular architecture of an RBM20-regulated single-locus subnuclear compartment organized around the TTN RNA
Evan E. Kania, Sara Bianchi, Aidan M. Fenix, Daphnée M. Marciniak, Shuai Li, Qiaoyi Lin, Marilu Casini, Borislav Hrisimirov Hristov, Lukasz Truszkowski, Nicholas G. Skiados, Milad Mokhtaridoost, Conor K. Camplisson, Elisabeth Wyart, Silvia Marchianò, Rose Fields, , David M Shechner
The paper uses O-MAP to study a cardiac-specific RNA factory around TTN RNA, revealing its chromatin interactions, RNA composition, and role of RBM20 in gene regulation.
bioRxiv · Nov 5, 2024 · PreprintGenomics