Robert J. Schwarz

Expression trajectories in the aging male mouse colon transcriptome

This study identifies nonlinear gene-expression trajectories in the aging male mouse colon, revealing midlife transitions and a transcriptomic clock based on three genes.

An improved epigenetic age estimation with TFMethyl Clock reveals DNA methylation changes during aging in transcription factor binding sites

The paper improves epigenetic age estimation by developing a TFMethyl Clock model that incorporates transcription factor binding sites, revealing DNA methylation changes linked to aging.

The Tgf-β family member Gdf6Y determines the male sex in Nothobranchius furzeri by suppressing oogenesis-inducing genes

This study identifies Gdf6Y as the male sex-determining gene in Nothobranchius furzeri by suppressing female-specific genes through TGF-β signaling.

The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

TargetGeneReg 2.0 expands its database to include non-coding genes and new transcription factors, enabling analysis of gene regulation by p53, ΔNp63, and cell cycle signaling.