Author

Christopher J. Wedeles

GenentechORCID 0000-0002-0658-046XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Aaron Wong· 1 shared Ahmet Can BerkyurekiD· 1 shared Alexander ArlanticoiD· 1 shared Alexander R. AbbasiD· 1 shared Alper AkayiD· 1 shared Amena NabihiD· 1 shared Andréy S. ShawiD· 1 shared Angus I. LamondiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aaron Wong

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJan 13, 2026

Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis

Rojo A. Ratsimandresy, Emma Doran, Hart S. Dengler…·Mark S. Wilson

This study shows that blocking OSM and IL-6 reduces fibrosis and inflammation in pulmonary fibrosis by targeting their shared receptor and distinct pathways.

DOI 10.64898/2025.12.25.695625

mousehuman

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Molecular BiologyDevelopmental CellPeer-reviewedAug 1, 2017

The Aquarius/EMB-4 helicase licenses co-transcriptional gene silencing

Alper Akay, Tomás Di Domenico, Kin Man Suen…·Eric Alexander Miska

This study identifies the Aquarius/EMB-4 helicase as essential for initiating small RNA-induced co-transcriptional gene silencing in C. elegans by facilitating HRDE-1 complex engagement with nascent transcripts.

69 citations

C. elegansexperimental assay

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