Tyler Ellis Papp

This paper compares T-cell receptor-targeted lipid nanoparticles for mRNA delivery, finding CD7-targeting achieves highest efficiency due to rapid internalization.

This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This study evaluates in vivo anti-FAP CAR T therapy for MASH, showing reduced fibrosis and restored liver homeostasis through HSC depletion and immune modulation.

This study uses intravital imaging to show corneal endothelial cells can regenerate in mice, and develops a therapeutic approach using modified mRNA to stimulate regeneration in aged mice.