Mesut Berber

Rho-ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal via adherens junctions

This study shows that β-Catenin-driven hyperplasia in the adrenal cortex is mediated through Rho-ROCK signaling and Cat-dependent stabilization of adherens junctions.

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production

This study identifies WNT2B as a key regulator of adrenal aldosterone production, showing its role in zG function and linking its variants to primary aldosteronism and a new form of familial hypoaldosteronism.