The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.
Véronique Calleja, Jack C. Henry, Mathias Cobbaut, Joanne Sewell, Karine Rizzoti, Francesca Houghton, Stefan Boeing, Nneka Anyanwu, Sunita Varsani-Brown, Thomas J. A. Snoeks, Alejandro Suárez‐Bonnet, Simon Lawrence Priestnall, Neil Q. McDonald, Angus J.M. Cameron, Peter J. Parker
The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.
Science Signaling · Nov 4, 2025Peer-reviewedCancer Biology