Sunita Varsani-Brown

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

The paper tracks mesodermal cell migration and lineage during mouse gastrulation, revealing distinct progenitor behaviors and fate allocation in cardiac development.