Author

Joanne Sewell

Queen Mary University of London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Angus J.M. CameroniD· 2 shared Jack C. HenryiD· 2 shared Neil Q. McDonaldiD· 2 shared Adam M. PassmaniD· 1 shared Alejandro Suárez‐BonnetiD· 1 shared Ashley CampbelliD· 1 shared Francesca HoughtoniD· 1 shared Ivan Quétier· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Angus J.M. CameronORCID

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2 papers

Recent·Most cited

PKN2 regulates cell-junctions to limit colitis

Jack C. Henry, Ashley Campbell, Prerana Huddar, Joanne Sewell, Shinelle Menezes, Adam M. Passman, Kane Smith, Shannah McGauran, Ivan Quétier, Meng‐Lay Lin, Marnix Jansen, Neil Q. McDonald, Trevor A. Graham, Stuart McDonald, Angus J.M. Cameron

This study identifies PKN2 as a regulator of tight junctions that limits colitis and colorectal cancer by maintaining intestinal barrier integrity during inflammation.

bioRxiv · Jun 28, 2026 · PreprintCell Biology

The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.

Véronique Calleja, Jack C. Henry, Mathias Cobbaut, Joanne Sewell, Karine Rizzoti, Francesca Houghton, Stefan Boeing, Nneka Anyanwu, Sunita Varsani-Brown, Thomas J. A. Snoeks, Alejandro Suárez‐Bonnet, Simon Lawrence Priestnall, Neil Q. McDonald, Angus J.M. Cameron, Peter J. Parker

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

Science Signaling · Nov 4, 2025Peer-reviewedCancer Biology