Author

Juan Lorenzo Pablo

Broad InstituteORCID 0000-0002-0804-9074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Anna GrekaiD· 3 shared Dylan Boone· 2 shared Maria Kost‐AlimovaiD· 2 shared Alissa C. GossiD· 1 shared Andrew Nelson· 1 shared Brianna R. Silverman· 1 shared Carolline Rodrigues MenezesiD· 1 shared Choah KimiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

Anna GrekaORCID

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3 papers

Recent·Most cited

Double-bond geometry determines fatty acid metabolic fate and ferroptosis sensitivity

Cynthia A. Harris, Shunji Kato, Yurika Otoki, Elisa Martin Perez, Dylan Boone, Juan Lorenzo Pablo, Anna Greka, James A. Olzmann

This study shows that fatty acid double-bond geometry affects metabolic fate and ferroptosis sensitivity by altering lipid composition and enzyme recognition.

bioRxiv · Jul 20, 2026 · PreprintCell Biology

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies

Magdalena Riedl Khursigara, Alissa C. Goss, Maria Kost‐Alimova, Keith H. Keller, Christine Danielle De Mata, Ranjithmenon Muraleedharan, Edward Ryan Collantes, Matthew Brown, Elizabeth J. Grinkevich, Felichi Mae Arines, John Lin, Patrick Byrne, Silvana Bazúa‐Valenti, Elizabeth Morici, Julie Roignot, , Anna Greka

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Choah Kim, Katlyn R. Gabriel, Dylan Boone, Matthew Brown, Katherine G. Oppenheimer, Maria Kost‐Alimova, Juan Lorenzo Pablo, Anna Greka

This study identifies FAF2 as a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses through a CRISPR knockout screen in human cells.

Science Advances · Jul 2, 2025Peer-reviewedCell Biology