Author

Sarah J. Coulthurst

University of DundeeORCID 0000-0002-0808-1875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:yeast· 1

Frequent Co-Authors

Genady PankoviD· 3 shared Andrew Michael FreyiD· 2 shared Colin RickmaniD· 2 shared Janet QuinniD· 2 shared Matthias TrostiD· 2 shared Adam OstrowskiiD· 1 shared Alex Anderton· 1 shared Alp Tegin ŞahiniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

Genady PankovORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An Rhs effector uses distinct target cell functions to intoxicate bacterial and fungal competitors

Gabriela M. Avelar, Genady Pankov, Tina Sarapa, Janet Quinn, William N. Hunter, Colin Rickman, Sarah J. Coulthurst

This study identifies Rhs2 as a dual-kingdom T6SS effector that targets bacterial and fungal cells through distinct mechanisms, revealing how a single effector can act against different cellular architectures.

bioRxiv · Sep 8, 2026Microbiology

Global identification of Chromobacterium violaceum T6SS effectors reveals an Rhs antibacterial toxin featuring FIX and ADP-ribosyltransferase domains

Júlia A. Alves, Genady Pankov, Andrew Michael Frey, Matthias Trost, Germán G. Sgro, Sarah J. Coulthurst, José F. da Silva Neto

This study identifies and characterizes novel T6SS effectors in Chromobacterium violaceum, revealing RhsF as an antibacterial toxin with FIX and ADP-ribosyltransferase domains.

Journal of Biological Chemistry · Jun 1, 2026Peer-reviewedBiochemistry

Tvp complexes support formation of the VgrG-PAAR spike during Type VI secretion system assembly

Laura Monlezun, Christopher Earl, Sarah J. Coulthurst

The paper identifies Tvp complexes essential for assembling the VgrG-PAAR spike in T6SSs and shows their role in effector delivery in Serratia marcescens.

The EMBO Journal · May 29, 2026Peer-reviewedMicrobiology

The Type VI Secretion System Antifungal Effector Tfe2 Inhibits Protein Translation and Drives Hyperactivation of TORC1.

Katharina Trunk, Genady Pankov, Alex Anderton, Viktoras Stonys, Andrew Michael Frey, Jennifer H. Haggarty, Ian Leaves, Pantelitsa Papakyriacou, Mengchun Li, Vivek Manthri, Flávia M. Zimbres, Paul William Denny, Phillip D. Whitfield, Christian Hacker, Neil A. R. Gow, , Janet Quinn

This study identifies Tfe2 as a novel antifungal effector that inhibits protein translation and hyperactivates TORC1, leading to cellular remodeling in yeast.

bioRxiv · Nov 20, 2025 · PreprintMicrobiology

A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system

Mark Reglinski, Quenton W. Hurst, David Joe Williams, Marek Gierliński, Alp Tegin Şahin, Katharine Mathers, Adam Ostrowski, Megan Bergkessel, Ulrich Zachariae, Samantha Jane Pitt, Sarah J. Coulthurst

This paper identifies a new family of T6SS pore-forming effectors in Serratia marcescens, showing distinct ion selectivity and broader target range compared to existing toxins.

The EMBO Journal · Oct 21, 2025Peer-reviewedMicrobiology