Author

Ozge Somuncu

Harvard UniversityORCID 0000-0002-0841-8263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 1 shared Dmitry M. KorzhneviD· 1 shared Emilie J. KorchakiD· 1 shared Gabriella A. ZambranoiD· 1 shared Irina BezsonovaiD· 1 shared Nicholas William AshtoniD· 1 shared Ramya RavindranathaniD· 1 shared Shuhei AsadaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Alan D. D’AndreaORCID

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1 paper

Recent·Most cited

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

Nicholas William Ashton, Ramya Ravindranathan, Emilie J. Korchak, Ozge Somuncu, Gabriella A. Zambrano, Sirisha Mukkavalli, Shuhei Asada, Dmitry M. Korzhnev, Irina Bezsonova, Alan D. D’Andrea

This paper identifies a PIP motif in RAD18 essential for PCNA ubiquitination and shows USP1 inhibition leads to synthetic lethality in BRCA1-deficient cells.

bioRxiv · May 10, 2026 · PreprintBiochemistry