Franck Mauvais‐Jarvis

Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes

The paper uses supervised machine learning to identify impaired mitochondrial quality control in β cells associated with type 2 diabetes using single-cell RNA sequencing data.

Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.

The paper examines sex and race differences in human pancreatic islets using scRNA-seq and snATAC-seq, finding sex-specific gene expression and chromatin accessibility differences in β cells that change with type 2 diabetes.

Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males

This paper identifies a MAFA S64F variant causing sex-dependent β cell dysfunction and diabetes by accelerating aging and senescence in males.

Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance

This study shows that deleting the hepatic androgen receptor in female mice prevents androgen-induced insulin resistance and glucose intolerance.