Stephen D. Ginsberg

Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

The paper performs single-cell transcriptomic and proteomic analysis of Parkinson's disease brains, identifying cell-type-specific changes and differences from Alzheimer's disease.

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

Epigenome-wide profiling in the dorsal raphe nucleus highlights cell-type-specific changes in TNXB in Alzheimer's disease

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimers disease neuropathology in a mouse model

The paper examines mossy fiber BDNF protein stability in AD mouse models and finds it remains unchanged with age, correlating with neuronal activity and resistance to amyloid-beta accumulation.

Translational neurophysiological biomarkers of N-methyl-D-aspartate receptor dysfunction in serine racemase knockout mice

The paper evaluates rodent auditory biomarkers as translational markers for NMDAR dysfunction and supports SRKO mice as a model for PV interneuron dysfunction in schizophrenia.