Author

Sean N. Avedissian

University of Nebraska Medical CenterORCID 0000-0002-0935-6455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Ákos VégváriiD· 1 shared Anne‐Grete MärtsoniD· 1 shared Anoop T. AmbikaniD· 1 shared Arpan AcharyaiD· 1 shared Ashley N. BrowniD· 1 shared Evelyn J. Franco· 1 shared J. G. Coen van HasseltiD· 1 shared Jérémie GuedjiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSystems Biology

Ákos VégváriORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintSep 24, 2025

Late treatment initiation leads to reduced antiviral potency

Xuanlin Liu, Evelyn J. Franco, Sean N. Avedissian…·Anne‐Grete Märtson

This study shows that late antiviral treatment initiation reduces drug potency (EC50), and a time-varying EC50 model better fits viral load data than a constant EC50 model.

DOI 10.1101/2025.09.24.678199

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Systems BiologybioRxivPreprintFeb 25, 2024

TISSUE-SPECIFIC METABOLOMIC REPROGRAMMING DETERMINES THE DISEASE PATHOPHYSIOLOGY OF SARS-COV-2 VARIANTS IN HAMSTER MODEL

Urvinder Kaur Sardarni, Anoop T. Ambikan, Arpan Acharya…·Siddappa N. Byrareddy

The paper investigates tissue-specific metabolic reprogramming and gut dysbiosis in hamsters infected with SARS-CoV-2 variants, revealing differences in viremia, metabolic responses, and microbiota composition between delta and omicron variants.

DOI 10.1101/2024.02.25.581989

mousemetabolomics

𝕏 PostBluesky