Author

Yun Lu

Rockefeller UniversityORCID 0000-0002-0992-9399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Shai ShahamiD· 6 shared Olya YarychkivskaiD· 2 shared Wolfgang W. KeiliD· 2 shared Yupu LiangiD· 2 shared Alina RashidiD· 1 shared Amelia FarinasiD· 1 shared Andrea J. BaeiD· 1 shared Anupriya SinghaliD· 1 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersNeuroscience

Shai ShahamORCID

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6 papers

Recent·Most cited

Non-apoptotic death of the C. elegans linker cell is primed by MYRF-1 activation of pqn-41/polyQ

Olya Yarychkivska, Simin Liu, Lauren Bayer Horowitz, Shiloh Newland, Peipei Wu, Saiya Mittal, Shogo Tamura, Tetiana Novosolova, David Faulkner Ritter, Yun Lu, Sevinç Ercan, Christopher M. Hammell, Shai Shaham

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

bioRxiv · Dec 11, 2025 · PreprintCell Biology

C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

Olya Yarychkivska, Lena M. Kutscher, Betty Ortiz Bido, Juliana Kagan, Yoon A. Kim, Dana Mamriev, Yun Lu, Elli Puscher, Wolfgang Keil, Sarit Larisch, Shai Shaham

The paper shows that CED-3 caspase in C. elegans promotes non-apoptotic linker cell dismantling but not death onset, and reveals similar mechanisms in mouse cells.

bioRxiv · Oct 15, 2025 · PreprintCell Biology

Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

Katherine C. Varandas, Brianna M. Hodges, Lauren Lubeck, Amelia Farinas, Yupu Liang, Yun Lu, Shai Shaham

The paper shows that glia in C. elegans detect and respond to dendrite structure damage by altering gene expression and secreting proteins, with specific proteins required for this response.

Nature Communications · Jan 2, 2025Peer-reviewedNeuroscience

A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

Alina Rashid, Maya Tevlin, Yun Lu, Shai Shaham

The paper identifies a cell-division-independent pathway for epithelial-to-motoneuron transformation in C. elegans, revealing regulatory mechanisms involving Notch, Ngn, and cytoskeletal genes.

Cell Reports · Sep 1, 2022Peer-reviewedNeuroscience

C. elegans REMO-1, a glial GPCR, regulates stress-induced nervous system remodeling and behavior

In Hae Lee, Carl Procko, Yun Lu, Shai Shaham

Cell Reports · Jan 1, 2021Peer-reviewedNeuroscience

Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5

Menachem Katz, Francis Corson, Wolfgang W. Keil, Anupriya Singhal, Andrea J. Bae, Yun Lu, Yupu Liang, Shai Shaham

Nature Communications · Apr 23, 2019Peer-reviewedNeuroscience