Author

Michael Rodrigues Costa

GenentechORCID 0000-0002-1011-0292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Jean‐Philippe FortiniD· 2 shared Aaron LictaoiD· 1 shared Benjamin T. WaltersiD· 1 shared Brett M. BabiniD· 1 shared Bridget Hoag· 1 shared Caroline L. GilchristiD· 1 shared Elisia VillemureiD· 1 shared Hanna G. BudayevaiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Jean‐Philippe FortinORCID

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2 papers

Recent·Most cited

Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22

Elisia Villemure, Robert L. Yauch, Joachim Rudolph, Tom Januario, Mingshuo Zeng, Hanna G. Budayeva, Benjamin T. Walters, Aaron Lictao, Sherry K. Li, Xiaofen Ye, Caroline L. Gilchrist, Bridget Hoag, Nicholas Endres, Peter Hsu, John Chan, , Joyce Liu

This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.

bioRxiv · Mar 5, 2025 · PreprintCancer Biology

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

Jean‐Philippe Fortin, Jenille Tan, Karen E. Gascoigne, Peter M. Haverty, William F. Forrest, Michael Rodrigues Costa, Scott E. Martin

The paper analyzes how multi-target sgRNAs in CRISPR screens introduce biases in essentiality scores and functional networks.

Genome biology · Jan 25, 2019Peer-reviewedBioinformatics