Yu Kang T. Xu

The paper shows microglia extract proteolytic organelles from neurons via a process called skoupocytosis, which bypasses retrograde transport and aids neuronal homeostasis.

This paper introduces a self-adaptive oblique plane microscopy technique that enables high-speed volumetric imaging across microscopic to macroscopic scales in multi-cellular systems.

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

The paper maps oligodendrocyte organization and dynamics across the mouse lifespan, revealing age- and region-specific differences in oligodendrogenesis and resilience.

The paper develops a deep learning image restoration method to enhance in vivo synaptic imaging resolution using ex vivo super-resolution techniques, enabling tracking of synaptic plasticity in living mice.

This paper introduces an automated cell tracking pipeline, Oligo-Track, to analyze oligodendrocyte dynamics in vivo, revealing suppressed oligodendrogenesis in deeper cortical layers after demyelination.

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.

This paper develops a deep learning method to quantify oligodendrocyte ensheathment in vitro, achieving accuracy comparable to human experts and enabling high-throughput analysis.