Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo
Sabah Mozafari, Laura Julia Starost, Blandine Manot-Saillet, Beatriz García-Díaz, Yu Kang T. Xu, Delphine Roussel, Marion J. F. Levy, Linda Ottoboni, Kee-Pyo Kim, Hans Robert Schöler, Timothy E. Kennedy, Jack Perry Antel, Gianvito Martino, Marı́a Cecilia Angulo, Tanja Kuhlmann, Anne Baron‐Van Evercooren
The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.
Science Advances · Dec 4, 2020Peer-reviewedNeuroscience