Tom van der Poll

Flagellin-mediated TLR5 activation enhances innate immune responses in healthy and diseased human airway epithelium

This study shows flagellin activates TLR5 in human airway epithelium, enhancing immune responses in both healthy and diseased states, but not directly reducing bacterial load.

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium

The paper identifies a novel framework to quantify immune dysregulation in critical illness by analyzing transcriptomic data across multiple cohorts.

A bioenergetic basis for multiorgan dysfunction in sepsis

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.