Rosie May Walker

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

The paper examines DNA methylation at the APOE gene in blood samples to assess its association with cholesterol, cognition, and risks of Alzheimer’s and cardiovascular disease.

This study identifies 29 differentially methylated sites associated with respiratory function and COPD, showing improved prediction of COPD risk when added to clinical models.

The paper assesses DNA methylation profiles from dried blood spots (DBS) compared to EDTA tubes and finds they are highly correlated and suitable for epigenetic studies.

This paper introduces a Bayesian method to estimate epigenetic associations with complex traits, finding that methylation data captures significant variance in BMI and smoking behavior.

The paper examines DNA methylation patterns in smokers and former smokers to determine how exposure duration and dose affect methylation changes and their reversal after cessation.

The paper improves age prediction from DNA methylation using larger datasets, showing reduced error and limitations in capturing biological ageing variation.

The paper develops DNA methylation predictors for BMI, smoking, alcohol, and education, finding they explain some phenotypic variance and predict mortality for some traits.

The paper examines the relationship between DNA methylation age acceleration and Alzheimer’s disease risk factors, finding significant associations with BMI, cholesterol ratios, socioeconomic status, and smoking behavior.

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.