Mairead L. Bermingham

This study shows that loss of SORCS2 increases DNA double-strand breaks in neurons, linking it to neurodegenerative processes.

This study identifies epigenome-wide DNA methylation differences between APOE ε4 and ε2 carriers in whole blood, implicating lipid-related genes.

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

This study links birth weight to adult health outcomes and DNA methylation differences, identifying a significant CpG site and associations with biological aging markers.

The paper identifies DNA methylation signatures associated with dementia risk factors in blood samples from individuals without Alzheimer's disease.

This study identifies DNA methylation loci associated with age-by-sex interactions in a cohort of 2,586 individuals, finding most significant loci are X-linked and linked to disease-related genes.

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

The paper examines DNA methylation at the APOE gene in blood samples to assess its association with cholesterol, cognition, and risks of Alzheimer’s and cardiovascular disease.

This study identifies 29 differentially methylated sites associated with respiratory function and COPD, showing improved prediction of COPD risk when added to clinical models.

The paper examines DNA methylation patterns in smokers and former smokers to determine how exposure duration and dose affect methylation changes and their reversal after cessation.

The paper develops DNA methylation predictors for BMI, smoking, alcohol, and education, finding they explain some phenotypic variance and predict mortality for some traits.