Xiaofang Tang

Precision culturomics enabled by unlabeled single-cell morphology and Raman spectra

This paper introduces a precision culturomics method using single-cell morphology and Raman spectra to sort and analyze microbial cells, revealing antibiotic-driven resistance and mutations in gut commensals.

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Endothelial AGO1 Drives Vascular Inflammation and Atherosclerosis via a Non-Canonical Nuclear Mechanism

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis

This study identifies ZNHIT1's role in meiotic progression by regulating H2A.Z deposition and gene expression during pachytene in male meiosis.

Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

This study shows that glucose-regulated O-GlcNAcylation of DNMT1 inhibits its methyltransferase activity, leading to epigenome changes and increased DNA damage.

Morphological profile determines the frequency of spontaneous calcium events in astrocytic processes

The paper identifies that thin astrocytic processes with high surface-to-volume ratios generate more spontaneous Ca2+ events due to increased baseline fluctuations and CICR.