Rachel E. Hayward

ESCAPE identifies covalent ligand-protein interactions by using prime editing to disrupt cysteine residues and assesses their impact on cellular phenotypes.

This study uses a chemical degradation system to show FOXA1 opens chromatin exclusively at its binding sites, activating or repressing transcription based on the chromatin environment.

This study investigates the effects of ENL YEATS domain inhibitors in leukemia models, finding that suppression of ENL target genes is not sufficient to explain their anti-leukemia effects.

The paper identifies inhibitors of the GRPEL1-HSPA9 chaperone complex using tryptoline stereoprobes and shows they target non-orthosteric sites.

The paper identifies subfunctionalized J-domain proteins in Arabidopsis thaliana that remodel protein aggregates, showing distinct stress responses and interactions with Hsp101.