Richard K. Grencis

IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity

This study identifies CD45 as a tuft cell-intrinsic checkpoint that limits intestinal type 2 immunity through an IL-13-induced negative feedback mechanism.

Caecal epithelium-derived thymic stromal lymphopoietin is not required for protective immunity against whipworm

This study shows that caecal epithelium-derived TSLP is not required for protective immunity against whipworm, but non-epithelial TSLP upregulation during infection is critical.

The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors

This paper identifies p43 as a lipid-binding protein secreted by Trichuris whipworms that modulates host immune responses by interacting with signaling lipids.

Host microbiome determines host specificity of the human whipworm, Trichuris trichiura

This study shows that the human whipworm's host specificity is driven by the host microbiome, using a humanized-microbiota mouse model and metagenomic analysis.

Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent

This study identifies serine proteases as key mediators of whipworm egg hatching induced by bacterial contact, revealing bacterial and larval enzyme interactions.