David Goulding

This study develops a human epithelial co-culture system that supports Treponema pallidum growth and identifies two distinct host-cell interaction behaviors.

This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.

The paper develops an in vitro model of CD8 T cell exhaustion and identifies a gene signature that defines the exhausted state in both in vitro and in vivo settings, with validation in human tumor samples.

This study identifies serine proteases as key mediators of whipworm egg hatching induced by bacterial contact, revealing bacterial and larval enzyme interactions.

The paper introduces genetically encoded fluorescent tags for Treponema pallidum and Sf1Ep cells to enhance visualization and study host-pathogen interactions in syphilis research.

This study shows that Adgrd1 regulates oviductal fluid flow and embryo transport in mice, with its absence causing infertility due to impaired embryo release from the ampullary-isthmic junction.

The paper uses TraDIS to identify genes involved in twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa, revealing both known and novel components.