Franziska Auer

T-Rex: Standardized Analysis of Germline Variants in Whole-Exome Sequencing Trios

T-Rex provides a standardized, no-programming-required tool for analyzing whole-exome sequencing trio data, achieving high precision and sensitivity in variant calling and filtering.

Diverging routes of oligodendrocyte recruitment in adaptive and regenerative myelination

This study compares oligodendrocyte recruitment in adaptive and regenerative myelination using zebrafish, showing distinct transcriptional programs and Gpr17-dependent pathways.

Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio)

This study uses chemogenetic tools to investigate the role of Purkinje cells in postural control of larval zebrafish, showing their impact on pitch-axis posture and fin-body coordination.

A brainstem circuit for gravity-guided vertical navigation

This study identifies a brainstem circuit in larval zebrafish that converts gravitational signals into vertical navigation by maintaining consistent heading.

Scalable Apparatus to Measure Posture and Locomotion (SAMPL): a high-throughput solution to study unconstrained vertical behavior in small animals

The paper introduces SAMPL, a high-throughput system for measuring posture and locomotion in small animals, demonstrating its use in zebrafish and showing genetic and developmental effects on movement.

Clinical criteria for genetic testing in pediatric oncology show a low specificity and miss every 4th child carrying a cancer predisposition

The paper evaluates clinical checklists for genetic testing in pediatric oncology, finding low specificity and missing 25% of children with cancer predisposition variants.